Fort Wayne is the 2nd largest city in Indiana. It has a population of about 270,000 as of the 2020 Census and is a 2-5 hour drive from many other major cities in the Midwest including Chicago, Indianapolis, Columbus, and Detroit. Fort Wayne has several big businesses like GM, Parkview Hospital, and Amazon. The city also has an international airport. With an affordable standard of living and warm, Midwest vibe, Fort Wayne is a great place to live.